Expression of the NMDA receptor in the rat model of orchialgia / 中华男科学杂志

Objective@#To explore the expression of the N-methyl-D-aspartate (NMDA) receptor in the rat model of orchialgia and its possible mechanisms.@*METHODS@#According to Yoshioka's method, the male rats in the control group were injected with 0.2 ml saline, and those in the experimental group with 0.2 ml 2% acetic acid solution. Then we tested the behavioral responses of the rats and determined the expressions of the subunits NR1 and NR2B of the NMDA receptor in the dorsal root ganglion and spinal dorsal horn by Western blot, RT-qPCR and immunofluorescence staining.@*RESULTS@#The withdrawal latency was decreased in the model rats, reaching the lowest value at 4 hours after modeling, significantly lower than in the controls (［4.15 ± 0.84］ vs ［12.32 ± 1.05］, P 0.05).@*CONCLUSIONS@#The NMDA receptor plays an important role in pathogenesis of orchialgia in rats. In the early stage of pain, upregulating the expression of the subunit NR2B of the NMDA receptor can mediate peripheral hyperalgesia and consequently orchialgia.

Clinicopathologic analysis of myocardial infarction with or without left ventricular aneurysm formation in the elderly patients / 中华心血管病杂志

<p><b>OBJECTIVE</b>To analyze the clinic-pathologic features of elderly myocardial infarction patients (> 60 years) with and without left ventricular aneurysm formation.</p><p><b>METHODS</b>Between January 1980 and October 2009, 107 myocardial infarction patients were divided into aneurysm group (n = 31) and non-aneurysm group (n = 76) according to autopsy results and the clinic-pathologic features of the two groups were compared.</p><p><b>RESULTS</b>Previous angina pectoris history was significantly less in aneurysm group than in non-aneurysm group [45.2% (14/31) vs. 92.1% (70/76), P = 0.047]. Incidence of hypertension was significantly higher in aneurysm group than in non-aneurysm group [77.4% (24/31) vs. 36.8% (28/76), P = 0.033]. The percentage of single-vessel disease [54.8% (17/31) vs. 23.7% (18/76), P = 0.033] and the LAD disease [96.8% (30/31) vs. 51.3% (39/76), P = 0.048] were both significantly higher in aneurysm group than in non-aneurysm group. Heart failure and ventricular arrhythmias were more likely the cause of death in patients with aneurysm than patients without aneurysm [56.3% (18/31) vs. 19.7% (15/76), P = 0.007]. Aneurysm mostly located in left ventricular anterior wall and apex.</p><p><b>CONCLUSIONS</b>Our results suggest that patients with left ventricular aneurysm formation are more likely to have hypertension, single-vessel disease and LAD disease, heart failure and ventricular arrhythmias but less previous angina pectoris than patients without left ventricular aneurysm formation. The common locations of ventricular aneurysm formation were left ventricular anterior wall and apex.</p>

Clinicopathologic and radiologic features of dysembryoplastic neuroepithelial tumors / 中华病理学杂志

<p><b>OBJECTIVE</b>To study the clinicopathologic features and radiologic findings of dysembryoplastic neuroepithelial tumor (DNT).</p><p><b>METHODS</b>The clinical presentations, radiologic findings, histologic features and immunophenotype of 9 cases of DNT were analyzed.</p><p><b>RESULTS</b>The age of patients ranged from 12 to 51 years (mean age = 32 years). Most presented with partial seizures, sometimes accompanied by transient aphasia, agraphia and decreased visual acuity. One case was asymptomatic and discovered incidentally during a routine check-up. All patients had no neurological deficit found on physical examination. All tumors were located in the supratentorial cerebral cortex. There was no peritumoral edema or space-occupying effect on radiologic examination. The tumors involved either frontal lobe (number = 4), temporal lobe (number = 4), frontoparietal lobe (number = 1) . Two cases showed cystic changes. Two histologic variants of DNT were recognized: simple (number = 3) and complex (number = 6). Simple variant was composed mainly of the glioneuronal element, accompanied by surrounding oligodendrocyte-like cells, and the complex variant contained a low-grade glioma component, in addition to the glioneuronal element and sometimes foci of cortical dysplasia.</p><p><b>CONCLUSIONS</b>DNT is a benign tumor with excellent prognosis after surgical excision. Local recurrence is rare. Complex variant of DNT needs to be distinguished from other types of low-grade glioma.</p>

CT perfusion of pulmonary carcinoma:the correlative study with fluoro-deoxyglucose positron emission tomography and tumor microvessel density / 中华放射学杂志

Objective To investigate the correlation between CT perfusion parameters of pulmonary carcinoma and standardized uptake values(SUV)derived from ~(18)F-fluoro-deoxyglucose positron emission tomography(~8F-FDG PET)and tumor microvessel density(MVD),and to determine the validity of CT perfusion in assessing tumor angiagenic activity of pulmonary carcinoma.Methods Fifty patients(mean age 57.5,17 females)with pulmonary carcinoma underwent CT perfusion using 16-slice helical CT.Blood flow(BF,ml?100g~(-1)?min~(-1)),blood volume(BV,ml?100g~(-1)),mean transmit time(MTF,s)and permeability surface area product(PS,ml?100g~(-1)?min~(-1))were analyzed.SUV of PET was calculated in 14 patients.The CD34 immunohistochemical staining was used for tumor microvessel counting.CT perfusion parameters of pulmonary carcinoma were correlatively studied with SUV and tumor MVD.Pearson's correlation analysis was performed to evaluate the association between CT perfusion parameters and SUV and MVD.Results The average values of BF,BV,MTT and PS were 97.30 ml?100g~(-1)?min~(-1), 8.86 ml?100g~(-1),6.75 s and 34.52 ml?100g~(-1)?min~(-1),respectively.The average value of MVD was 61.82/FOV.The mean value of SUV was 5.96.There was positive correlation between BF and SUV(r= 0.727,P